Publications
대표논문
Date: 19 October 1999

Journal: Journal of Experimental Medicine Volume 191, Issue 1, 3 January 2000, Pages 9-21 , Doi: 10.1084/jem.191.1.9

1999 | The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis…

Ann M. Rangera, Louis C. Gerstenfeldd, Jinxi Wangb, Tamiyo Kond,e, Hyunsu Baea, Ellen M. Gravallesec, Melvin J. Glimcherb and Laurie H. Glimchera,c

Abstract

Nuclear factor of activated T cells (NFAT) transcription factors regulate gene expression in lymphocytes and control cardiac valve formation. Here, we report that NFATp regulates chondrogenesis in the adult animal. In mice lacking NFATp, resident cells in the extraarticular connective tissues spontaneously differentiate to cartilage. These cartilage cells progressively differentiate and the tissue undergoes endochondral ossification, recapitulating the development of endochondral bone. Proliferation of already existing articular cartilage cells also occurs in some older animals. At both sites, neoplastic changes in the cartilage cells occur. Consistent with these data, NFATp expression is regulated in mesenchymal stem cells induced to differentiate along a chondrogenic pathway. Lack of NFATp in articular cartilage cells results in increased expression of cartilage markers, whereas overexpression of NFATp in cartilage cell lines extinguishes the cartilage phenotype. Thus, NFATp is a repressor of cartilage cell growth and differentiation and also has the properties of a tumor suppressor.

TITLE
 The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis 
JOURNAL
 Journal of Experimental Medicine
 Volume 191, Issue 1, 3 January 2000, Pages 9-21
 DOI
 10.1084/jem.191.1.9 (click 하시면 DOI 검색 결과가 새창으로 나타납니다.)
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