Date: 5 MAY 2010

Journal: GLIA Volume 58, Issue 10, 1 August 2010, Pages 1247-1256 , Doi: 10.1002/glia.21006

2010 | Foxp3 is a novel repressor of microglia activation…

Hwan-Suck Chung1, Jun-Ho Lee1, Hyunseong Kim1, Hyo-Jung Lee1, Sung-Hoon Kim2, Ho-Keun Kwon3, Sin-Hyeog Im3 and Hyunsu Bae1,*


Forkhead transcription factor3 (Foxp3) is critical for generating CD4+CD25+ regulatory T cells. However, its role in microglia has not been identified. Here, we show that Foxp3 is expressed in microglia and is upregulated upon activation. In Foxp3 mutant mice (Foxp3sf), microglia release higher levels of inflammatory cytokines and mediators such as NO, MCP-1, CXCL10, and ROS upon liposaccharide treatment than the wild type, while TNF-α and IL-1β were not significantly different between wild and mutant microglial cells. In addition, Foxp3 silencing enhances inflammatory responses, suggesting that the major role of Foxp3 in microglia is that of a repressor of activation. Similarly, Foxp3 overexpression reduces inflammatory responses in microglia. We also demonstrate that Foxp3 interacts directly with NF-κB and modulates its transcriptional activities. These findings point to the importance of Foxp3 in NF-κB mediated inflammatory responses in microglia. © 2010 Wiley-Liss, Inc.

 Foxp3 is a novel repressor of microglia activation 
 Volume 58, Issue 10, 1 August 2010, Pages 1247-1256
 10.1002/glia.21006 (click 하시면 DOI 검색 결과가 새창으로 나타납니다.)
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