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대표논문
Date: 25 August 2012

Journal: Brain, Behavior, and Immunity Volume 26, Issue 8, November 2012, Pages 1322-1330 , Doi: 10.1016/j.bbi.2012.08.013

2012 | Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson's disease: Role of regulatory T cells…

Eun Sook Chung, Himchan Kim, Gihyun Lee, Soojin Park, Hyunseong Kim, Hyunsu Bae

Abstract

In the present study, we sought to determine whether bee venom (BV) promotes the survival of dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD). Treatment with BV prevented degeneration of DA neurons in the substantia nigra (SN). This neuro-protective effect of BV was associated with microglial deactivation and reduction of CD4 T cell infiltration. Additionally, BV treatment significantly increased the proportion of CD4+CD25+Foxp3+ Tregs in vivo and in vitro. The increased proportion of Tregs by BV treatment remained suppressive ex vivo. Interestingly, BV treatment did not prevent MPTP neurotoxicity in mice depleted of Tregs by anti-CD25 antibody injection. Therefore, our present studies suggest that modulation of peripheral immune tolerance by Treg may contribute to the neuroprotective effect of BV in the MPTP model of Parkinson’s disease.

 TITLE
 Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson's disease: Role of regulatory T cells
 JOURNAL
 Brain, Behavior, and Immunity
 Volume 26, Issue 8, November 2012, Pages 1322-1330
 DOI
 10.1016/j.bbi.2012.08.013 (click 하시면 DOI 검색 결과가 새창으로 나타납니다.)
 
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