Abstract

The molecular effects of Saussurea lappa extracts, a traditional medicine in Eastern Asia, on the fate of gastric carcinoma have not been understood. In this study, its cytostatic effects were examined using gastric AGS cancer cells. Its treatment resulted in apoptosis and G2-arrest in a dose- and time-dependent manner. The effects were attributed to the regulation of cyclins and pro-apoptotic molecules and suppression of anti-apoptotic molecules. Therefore, these results suggest that extracts of S. lappa root may be a candidate to deal with gastric cancers either by traditional herbal therapy or by combinational therapy with conventional chemotherapy. © 2004 Elsevier Ireland Ltd. All rights reserved.

Author keywords

Apoptosis; ATM/ATR; Gastric cancer; Growth arrest; p53; Saussurea lappa

Indexed keywords

EMTREE drug terms: cycline; herbaceous agent; protein p53; Saussurea lappa extract

EMTREE medical terms: apoptosis; article; cancer cell; chemotherapy; cytostasis; growth disorder; herbal medicine; human; human cell; priority journal; regulatory mechanism; Saussurea; stomach cancer; timed drug release; traditional medicine

MeSH: Apoptosis; Cell Cycle; Cell Division; Humans; Plant Extracts; Saussurea; Stomach Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53
Medline is the source for the MeSH terms of this document.

Chemicals and CAS Registry Numbers: Plant Extracts; Tumor Suppressor Protein p53