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Date: August 2005

Journal: International Immunopharmacology Volume 5, Issue 9, August 2005, Pages 1406-1414 , Doi: 10.1016/j.intimp.2005.03.011

2005 | Bee venom modulates murine Th1/Th2 lineage development…

Nam, S.a, Ko, E.a, Park, S.-K.a, Ko, S.a, Jun, C.-Y.b, Shin, M.-K.a, Hong, M.-C.a, Bae, H.ac

Abstract

Administration of bee venom (BV) elicits anti-inflammatory, anti-nociceptive and anti-allergic effects in various animal models. This study was designed to evaluate the direct effects of BV on helper T cell activities and on Th1/Th2 lineage development using both in vitro and in vivo conditions. In the Th1 skewed condition, BV increased the expression of IFN-γ mRNA and enhanced the expression of T-bet on purified CD4+ T cells from splenocytes of BALB/c mice. On the other hand, BV treatment did not alter the expression of IL-4 or GATA-3 in a Th2 driven environment. To elucidate the effects of BV on Th1/Th2 lineage development under in vivo conditions, BV was given by intraperitonial injection to BALB/c mice. It significantly increased the CD4+ T cell population and enhanced IFN-γ expression, while IL-4 transcripts were not altered upon in vivo activation using an anti-CD3 antibody injection. Taken together, these results imply that BV induces Th1 lineage development from CD4+ T cells by increasing the expression of a Th1-specific cytokine, IFN-γ. In addition, this result may be mediated by inducing a Th1-specific transcription factor, T-bet. © 2005 Elsevier B.V. All rights reserved.


Author keywords

Bee venom; GATA-3; IFN-γ; IL-4; T-bet; Th1; Th2


Indexed keywords

EMTREE drug terms: antibody; bee venom; gamma interferon; interleukin 4; messenger RNA; transcription factor; transcription factor GATA 3; transcription factor T bet; unclassified drug

EMTREE medical terms: animal cell; animal experiment; article; cell lineage; controlled study; cytokine production; female; gene expression; lymphocyte subpopulation; mouse; nonhuman; priority journal; spleen cell; T lymphocyte activation; Th1 cell; Th2 cell

MeSH: Animals; Bee Venoms; Cell Lineage; DNA-Binding Proteins; GATA3 Transcription Factor; Interferon Type II; Interleukin-4; Mice; T-Box Domain Proteins; Th1 Cells; Th2 Cells; Trans-Activators; Transcription Factors
Medline is the source for the MeSH terms of this document.


Chemicals and CAS Registry Numbers: gamma interferon, 82115-62-6; transcription factor GATA 3, 137878-55-8;Bee Venoms; DNA-Binding Proteins; Gata3 protein, mouse; GATA3 Transcription Factor; Interferon Type II, 82115-62-6; Interleukin-4, 207137-56-2; T-Box Domain Proteins; T-box transcription factor TBX21; Trans-Activators; Transcription Factors


ISSN: 15675769 CODEN: IINMBSource Type: Journal Original language: English
DOI: 10.1016/j.intimp.2005.03.011 PubMed ID: 15953567 Document Type: Article
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