The immunosuppressive effects of Sophorae radix (SR) make this plant an attractive agent for the treatment of autoimmune diseases. The effect of SR on systemic lupus erythematosus (SLE) in the New Zealand Black/White F1 (NZB/w F1) mouse model system was investigated. Three-month-old NZB/w F1 mice were separated into two groups: one treated with SR (1% SR solution by oral administration, daily for 15 weeks) and one with water as a control. Experimental parameters include proteinuria, anti-dsDNA antibody titers, T-cell response and renal histopathological analysis. Results in the SR-treated group showed a significant reduction in proteinuria and anti-dsDNA antibodies either in serum or in glomerular capillaries, along with significant recovery from renal glomerular damage. The lymphocyte population was significantly increased in the SR-treated mice compared with the control group. In the T helper (Th)1/Th2 cytokine secretion profile, interferon-γ in splenocyte culture was significantly reduced in the SR-treated mice, while interleukin-4 secretion was not altered. These results strongly suggest SR therapy corrects the deviated Th1/Th2 balance, thereby alleviating SLE-like symptoms in the NZB/w F1 mice. Therefore, SR may be useful in the clinical treatment of SLE. © 2007 SAGE Publications.
SLE; Sophorae radix; Th1; Th2
EMTREE drug terms: double stranded DNA antibody; gamma interferon; plant extract; sophora radix extract; unclassified drug
EMTREE medical terms: animal experiment; animal model; animal tissue; antibody titer; article; cell culture; controlled study; cytokine release; female; histopathology; immune response; kidney injury; kidney parenchyma; lymphocyte subpopulation; mouse; New Zealand black mouse; nonhuman; priority journal; proteinuria; spleen cell; systemic lupus erythematosus
MeSH: Animals; Antibodies, Antinuclear; Autoimmunity; Blood Cell Count; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Female; Interferon Type II; Interleukin-4; Kidney; Lupus Erythematosus, Systemic; Mice; Mice, Inbred NZB; Spleen
Medline is the source for the MeSH terms of this document.
Chemicals and CAS Registry Numbers: gamma interferon, 82115-62-6;Antibodies, Antinuclear; Drugs, Chinese Herbal; Interferon Type II, 82115-62-6; Interleukin-4, 207137-56-2