Tyrosinase is a copper-containing enzyme, which is widely distributed in microorganisms, animals and plants and is a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional methods to prevent tyrosinase action encourages researchers to seek new potent tyrosinase inhibitors for food and cosmetics. This article presents a study on the importance of tyrosinase, biochemical characteristics, type of inhibitions, activators from various natural sources with its clinical and industrial importance in recent prospects is discussed in this paper. Copyright © 2007 John Wiley & Sons, Ltd.
Activators; Biochemical character; Clinical studies; Inhibitors; Tyrosinase
EMTREE drug terms: 5 hydroxymethylfurfural; 9 hydroxy 4 methoxypsorain; agaritine; aloesin; anacardic acid; anisaldehyde; anisic acid; arbutin; azelaic acid; benzoic acid; caffeic acid; cinnamaldehyde; cinnamic acid; cumic acid; cuminaldehyde; depigmenting agent; enzyme inhibitor; epicathechin 3 o gallate; epigallocatechin gallate; ferulic acid; flavonoid; kaempferol; kojic acid; melanin; monophenol monooxygenase; oxyresveratrol; para coumaric acid; quercetin; tyrosinase inhibitor; unclassified drug; unindexed drug
EMTREE medical terms: agriculture; antineoplastic activity; antioxidant activity; biochemistry; cancer inhibition; chemical analysis; cosmetic industry; drug mechanism; enzyme activity; enzyme analysis; enzyme mechanism; enzyme substrate; food industry; hyperpigmentation; IC 50; melanogenesis; melanoma; mutagenicity; nonhuman; oxidative stress; radiation exposure; review; skin; spectroscopy; stereospecificity; ultraviolet radiation; vitiligo
MeSH: Agriculture; Cosmetics; Humans; Peptides; Phytotherapy; Plants, Medicinal; Skin; Skin Care; Skin Pigmentation
Medline is the source for the MeSH terms of this document.
Species Index: Animalia; Mammalia
Chemicals and CAS Registry Numbers: 5 hydroxymethylfurfural, 67-47-0; agaritine, 2757-90-6; aloesin, 30861-27-9; anacardic acid, 11034-77-8; anisaldehyde, 123-11-5, 50984-52-6; anisic acid, 100-09-4; arbutin, 497-76-7; azelaic acid, 123-99-9; benzoic acid, 532-32-1, 582-25-2, 65-85-0, 766-76-7; caffeic acid, 27323-69-9, 331-39-5; cinnamaldehyde, 104-55-2; cinnamic acid, 4151-45-5, 538-42-1, 621-82-9; cumic acid, 536-66-3; cuminaldehyde, 122-03-2; epigallocatechin gallate, 989-51-5; ferulic acid, 1135-24-6, 24276-84-4; kaempferol, 520-18-3; kojic acid, 501-30-4; melanin, 8049-97-6; monophenol monooxygenase, 9002-10-2; para coumaric acid, 7400-08-0; quercetin, 117-39-5;Cosmetics; Peptides; tyrosinase inhibitor