Date: September 2007

Journal: Phytotherapy Research Volume 21, Issue 9, September 2007, Pages 805-816 , Doi: 10.1002/ptr.2184

2007 | Naturally occurring tyrosinase inhibitors: Mechanism and applications in skin health, cosmetics and agriculture industries…

Parvez, S.a , Kang, M.b, Chung, H.-S.b, Bae, H.b



Tyrosinase is a copper-containing enzyme, which is widely distributed in microorganisms, animals and plants and is a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional methods to prevent tyrosinase action encourages researchers to seek new potent tyrosinase inhibitors for food and cosmetics. This article presents a study on the importance of tyrosinase, biochemical characteristics, type of inhibitions, activators from various natural sources with its clinical and industrial importance in recent prospects is discussed in this paper. Copyright © 2007 John Wiley & Sons, Ltd.

Author keywords

Activators; Biochemical character; Clinical studies; Inhibitors; Tyrosinase

Indexed keywords

EMTREE drug terms: 5 hydroxymethylfurfural; 9 hydroxy 4 methoxypsorain; agaritine; aloesin; anacardic acid; anisaldehyde; anisic acid; arbutin; azelaic acid; benzoic acid; caffeic acid; cinnamaldehyde; cinnamic acid; cumic acid; cuminaldehyde; depigmenting agent; enzyme inhibitor; epicathechin 3 o gallate; epigallocatechin gallate; ferulic acid; flavonoid; kaempferol; kojic acid; melanin; monophenol monooxygenase; oxyresveratrol; para coumaric acid; quercetin; tyrosinase inhibitor; unclassified drug; unindexed drug

EMTREE medical terms: agriculture; antineoplastic activity; antioxidant activity; biochemistry; cancer inhibition; chemical analysis; cosmetic industry; drug mechanism; enzyme activity; enzyme analysis; enzyme mechanism; enzyme substrate; food industry; hyperpigmentation; IC 50; melanogenesis; melanoma; mutagenicity; nonhuman; oxidative stress; radiation exposure; review; skin; spectroscopy; stereospecificity; ultraviolet radiation; vitiligo

MeSH: Agriculture; Cosmetics; Humans; Peptides; Phytotherapy; Plants, Medicinal; Skin; Skin Care; Skin Pigmentation
Medline is the source for the MeSH terms of this document.

Species Index: Animalia; Mammalia

Chemicals and CAS Registry Numbers: 5 hydroxymethylfurfural, 67-47-0; agaritine, 2757-90-6; aloesin, 30861-27-9; anacardic acid, 11034-77-8; anisaldehyde, 123-11-5, 50984-52-6; anisic acid, 100-09-4; arbutin, 497-76-7; azelaic acid, 123-99-9; benzoic acid, 532-32-1, 582-25-2, 65-85-0, 766-76-7; caffeic acid, 27323-69-9, 331-39-5; cinnamaldehyde, 104-55-2; cinnamic acid, 4151-45-5, 538-42-1, 621-82-9; cumic acid, 536-66-3; cuminaldehyde, 122-03-2; epigallocatechin gallate, 989-51-5; ferulic acid, 1135-24-6, 24276-84-4; kaempferol, 520-18-3; kojic acid, 501-30-4; melanin, 8049-97-6; monophenol monooxygenase, 9002-10-2; para coumaric acid, 7400-08-0; quercetin, 117-39-5;Cosmetics; Peptides; tyrosinase inhibitor

ISSN: 0951418X CODEN: PHYRESource Type: Journal Original language: English
DOI: 10.1002/ptr.2184 PubMed ID: 17605157 Document Type: Review
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