Publications
기타논문
Date: April 2008
Journal: Peptides Volume 29, Issue 4, April 2008, Pages 564-570 , Doi: 10.1016/j.peptides.2008.01.002
2008 | The endogenous CCK mediation of electroacupuncture stimulation-induced satiety in rats…
- Kim, S.K.abc, Bae, H.bc , Lee, G.a, Jeong, H.a, Woo, H.S.d, Han, J.-B.a, Kim, Y.bc, Lee, H.e, Shin, M.-K.bc, Hong, M.-C.bc, Jin, Y.-H.f, Min, B.-I.af
Abstract
A major satiety hormone, cholecystokinin (CCK) is well known to be released by electroacupuncture (EA) stimulation at certain body sites which elicits profound psychophysiological responses. Previous clinical and animal studies have shown that EA stimulation reduces food intake and body weight in both normal and obese subjects. The aim of the present study was to elucidate the satiety effect of EA stimulation and its mechanism related to CCK in rats. Here we show that EA stimulation at "Zusanli" (ST36) acupoint significantly reduced 30-min and 60-min food intake in 48-h fasted Sprague-Dawley rats, and such effect was reversed by a lorglumide (CCK-1 receptor antagonist, 10 mg/kg, i.p.) pretreatment. The ST36 EA stimulation-induced satiety was not observed in CCK-1 receptor knockout, Otsuka Long-Evans Tokushima Fatty rats, but in their controls, Long-Evans Tokushima Otsuka rats. Subdiaphragmatic vagotomy also blocked the satiety effect of ST36 EA stimulation in Sprague-Dawley rats. These results suggest that ST36 EA stimulation elicits satiety in rats and this is mediated by the endogenous CCK signaling pathway. © 2008 Elsevier Inc. All rights reserved.
Author keywords
Cholecystokinin; Electroacupuncture; Lorglumide; Otsuka Long-Evans Tokushima Fatty rat; Satiety; Vagotomy
Indexed keywords
EMTREE drug terms: cholecystokinin; lorglumide
EMTREE medical terms: animal experiment; article; controlled study; drug effect; electroacupuncture; food intake; male; nonhuman; priority journal; rat; satiety; stimulation
MeSH: Animals; Cholecystokinin; Electroacupuncture; Fasting; Male; Proglumide; Rats; Rats, Inbred OLETF; Rats, Sprague-Dawley; Satiation
Medline is the source for the MeSH terms of this document.
Species Index: Animalia; Rattus
Chemicals and CAS Registry Numbers: cholecystokinin, 9011-97-6, 93443-27-7; lorglumide, 97964-56-2;Cholecystokinin, 9011-97-6; lorglumide, 97964-56-2; Proglumide, 6620-60-6