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기타논문
Date: October 2008

Journal: Journal of Physiological Sciences Volume 58, Issue 5, October 2008, Pages 357-360 , Doi: 10.2170/physiolsci.SC008308

2008 | Electroacupuncture potentiates the antiallodynic effect of intrathecal neostigmine in a rat model of neuropathic pain…

Kim, H.N.ab, Park, J.H.ab, Kim, S.K.cd, Sun, B.a, Koo, S.e, Choi, S.M.e, Bae, H.c, Min, B.-I.afg

첨부파일

Abstract

This study was performed to examine whether electroacupuncture potentiates the neostigmine-induced antiallodynia in neuropathic pain rats. Although intrathecal neostigmine (0.05, 0.1, and 0.3 μg) dose-dependently relieved cold allodynia, 0.3 μg neostigmine caused side effects. The coapplication of 0.1 μg neostigmine and electroacupuncture, however, produced potent antiallodynia, which was parallel to the effect of 0.3 μg neostigmine, without side effects. These results indicate that electroacupuncture can enhance the antiallodynic action of intrathecal neostigmine.


Author keywords

Electroacupuncture; Intrathecal neostigmine; Neuropathic pain


Indexed keywords

EMTREE drug terms: neostigmine

EMTREE medical terms: allodynia; animal experiment; animal model; article; controlled study; dose response; drug effect; electroacupuncture; electrostimulation; neuropathic pain; nonhuman; rat

MeSH: Animals; Cholinesterase Inhibitors; Combined Modality Therapy; Disease Models, Animal; Electroacupuncture; Injections, Spinal; Male; Neostigmine; Neuralgia; Rats; Rats, Sprague-Dawley
Medline is the source for the MeSH terms of this document.


Chemicals and CAS Registry Numbers: neostigmine, 114-80-7, 588-17-0, 59-99-4, 8048-84-8;Cholinesterase Inhibitors; Neostigmine, 59-99-4

Manufacturers:Drug manufacturer: Sigma.


ISSN: 18806546Source Type: Journal Original language: English
DOI: 10.2170/physiolsci.SC008308 PubMed ID: 18840324 Document Type: Article
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