Abstract

This study was performed to examine whether electroacupuncture potentiates the neostigmine-induced antiallodynia in neuropathic pain rats. Although intrathecal neostigmine (0.05, 0.1, and 0.3 μg) dose-dependently relieved cold allodynia, 0.3 μg neostigmine caused side effects. The coapplication of 0.1 μg neostigmine and electroacupuncture, however, produced potent antiallodynia, which was parallel to the effect of 0.3 μg neostigmine, without side effects. These results indicate that electroacupuncture can enhance the antiallodynic action of intrathecal neostigmine.

Author keywords

Electroacupuncture; Intrathecal neostigmine; Neuropathic pain

Indexed keywords

EMTREE drug terms: neostigmine

EMTREE medical terms: allodynia; animal experiment; animal model; article; controlled study; dose response; drug effect; electroacupuncture; electrostimulation; neuropathic pain; nonhuman; rat

MeSH: Animals; Cholinesterase Inhibitors; Combined Modality Therapy; Disease Models, Animal; Electroacupuncture; Injections, Spinal; Male; Neostigmine; Neuralgia; Rats; Rats, Sprague-Dawley
Medline is the source for the MeSH terms of this document.

Chemicals and CAS Registry Numbers: neostigmine, 114-80-7, 588-17-0, 59-99-4, 8048-84-8;Cholinesterase Inhibitors; Neostigmine, 59-99-4

Manufacturers:Drug manufacturer: Sigma.