Date: 17 May 2010

Journal: Brain Research Volume 1331, 17 May 2010, Pages 20-27 , Doi: 10.1016/j.brainres.2010.03.041

2010 | Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes…

Lee, J.-H.a, Lee, Y.-J.b, Kang, S.-W.a, Kim, Y.a, Shin, M.a, Hong, M.a, Seo, E.-K.b, Kim, S.-H.a, Nah, S.-Y.c, Bae, H.a


Alisol derivatives are unique protostane-type triterpenoid compounds that are isolated from Alismatis rhizoma, which is a well-known traditional medicine in East Asia. In the present study, we investigated the effects of protostane-type triterpenoids (AA, Alisol A; AB, Alisol B; AB-ac, Alisol B 23-acetate; AC-ac, Alisol C 23-aceteate) on 5-HT-induced currents mediated by the human 5-HT3A receptor expressed in Xenopus laevis oocytes. Co-treatment with triterpenoids regulated the 5-HT-induced inward peak current in a concentration-dependent and reversible manner. In addition, regulation of I5-HT by triterpenoids occurred in a non-competitive manner. Taken together, these results indicate that triterpenoids may regulate the 5-HT3A receptors that are expressed in Xenopus oocytes. Furthermore, this regulation of the ligand-gated ion channel activity by triterpenoids may be one of the pharmacological actions of Alismatis rhizoma. © 2010 Elsevier B.V. All rights reserved.

Author keywords

5-HT3A receptor; Triterpenoid; Two-electrode voltage clamp

Indexed keywords

EMTREE drug terms: alisol a; alisol b; alisol B 23 acetate; alisol C 23 aceteate; serotonin 3A receptor; triterpenoid; unclassified drug

EMTREE medical terms: animal cell; article; concentration (parameters); controlled study; ion current; ion transport; nonhuman; oocyte; priority journal; regulatory mechanism; transport kinetics; Xenopus

MeSH: Alismatidae; Animals; Cholestenones; Humans; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Plant Extracts; Receptors, Serotonin, 5-HT3; Xenopus
Medline is the source for the MeSH terms of this document.

Species Index: Xenopus laevis

Chemicals and CAS Registry Numbers: Cholestenones; Plant Extracts; Receptors, Serotonin, 5-HT3; alisol A, 19885-10-0; alisol B, 18649-93-9; alisol B 23-acetate

ISSN: 00068993 CODEN: BRREASource Type: Journal Original language: English
DOI: 10.1016/j.brainres.2010.03.041 PubMed ID: 20307506 Document Type: Article
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