Abstract

Taeeumjowitangkagambang (ETJKB) is a traditional Korean medicine that has been clinically used for obesity with little mechanistic understanding. The present study investigated antiobesity and hypolipidemic effects of ETJKB in high fat diet fed rats as well as a 3T3-L1 pre-adipocyte differentiation model. ETJKB significantly inhibited the lipidogenesis in 3T3-L1 adipocytes in a concentration-dependent manner as well as reduced the cellular adipokine leptin level. Daily oral gavage of ETJKB to rats fed a high fat diet significantly attenuated body weight gain and abdominal and epididymal fat weights. ETJKB treatment also reduced the levels of total cholesterol, low density lipoprotein (LDL) and triglyceride as well as increased high density lipoprotein (HDL) in serum compared with the untreated control. Similarly, the ETJKB treatment decreased the levels of total lipid, triglyceride and cholesterol in liver tissue in high fat diet fed rats. Interestingly, ETJKB significantly increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase in liver tissue, while decreasing the hydroxyl radical, thiobarbituric acid reactive substances (TBARS), carbonyl concentration. An improvement of antioxidant enzymes was associated with improved body weight control and healthier lipid profiles and therefore may play an important role in the antiobesity and hypolipidemic effects of ETJKB. © 2010 John Wiley & Sons, Ltd.

Author keywords

Antioxidant enzymes; Hyperlipidemia; Obesity; Taeeumjowitangkagambang

Indexed keywords

EMTREE drug terms: antilipemic agent; antiobesity agent; catalase; glutathione peroxidase; herbaceous agent; leptin; low density lipoprotein; superoxide dismutase; taeeumjowitangkagambang; triacylglycerol; unclassified drug

EMTREE medical terms: adipocyte; animal cell; animal experiment; animal model; antioxidant activity; article; controlled study; drug inhibition; enzyme activity; epididymis fat; high performance liquid chromatography; hyperlipidemia; Korean medicine; lipid blood level; lipid diet; lipid storage; male; nonhuman; obesity; rat; weight gain

MeSH: 3T3-L1 Cells; Animals; Anti-Obesity Agents; Antioxidants; Body Weight; Catalase; Cholesterol; Glutathione Peroxidase; Hypolipidemic Agents; Leptin; Lipid Peroxidation; Lipoproteins, LDL; Liver; Male; Medicine, Korean Traditional; Mice; Plant Extracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triglycerides
Medline is the source for the MeSH terms of this document.

Species Index: Rattus

Chemicals and CAS Registry Numbers: catalase, 9001-05-2; glutathione peroxidase, 9013-66-5; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1;Anti-Obesity Agents; Antioxidants; Catalase, 1.11.1.6; Cholesterol, 57-88-5; Glutathione Peroxidase, 1.11.1.9; Hypolipidemic Agents; Leptin; Lipoproteins, LDL; Plant Extracts; Superoxide Dismutase, 1.15.1.1; Thiobarbituric Acid Reactive Substances; Triglycerides