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Date: December 2010

Journal: Phytotherapy Research Volume 24, Issue 12, December 2010, Pages 1781-1787 , Doi: 10.1002/ptr.3161

2010 | Antiinflammatory effects of Epimedium brevicornum water extract on lipopolysaccharide-activated RAW264.7 macrophages…

Yuk, S.-S.a, Lim, E.-M.a, Lee, J.Y.a, Lee, Y.-J.a, Kim, Y.-S.a, Lee, T.H.a, Park, S.K.b, Bae, H.b, Kim, H.M.b, Ko, S.-G.b, Oh, M.S.c, Park, W.a

Abstract

Epimedium brevicornum Maxim (Berberidaceae) possesses estrogenic properties. It is one of the most widespread herbal remedies used in Oriental medicine. The present study investigated the effects of Epimedium brevicornum water extract (EB) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced RAW264.7 macrophages. EB significantly inhibited the production of nitric oxide (NO), interleukin (IL)-3, IL-10, IL-12p40, interferon-inducible protein-10, keratinocyte-derived chemokine, vascular endothelial growth factor, monocyte chemotactic protein-1 and granulocyte macrophage-colony stimulating factor in LPS-induced RAW264.7 cells at concentrations of 25, 50, 100 and 200 μg/mL (p < 0.05). These results suggest that EB has antiinflammatory activity related to its inhibition of NO, cytokine, chemokine and growth factor production in macrophages. Copyright © 2010 John Wiley & Sons, Ltd.


Author keywords

antiinflammatory; Berberidaceae; cytokine; Epimedium brevicornum; macrophage; nitric oxide


Indexed keywords

EMTREE drug terms: cyclooxygenase 1; cyclooxygenase 2; Epimedium extract; gamma interferon inducible protein 10; granulocyte macrophage colony stimulating factor; interleukin 10; interleukin 12p40; interleukin 17; interleukin 3; keratinocyte derived chemokine; lipopolysaccharide; monocyte chemotactic protein 1; nitric oxide; prostaglandin E2; RANTES; vasculotropin

EMTREE medical terms: animal cell; antiinflammatory activity; article; cell viability; concentration response; controlled study; cytokine production; drug effect; Epimedium; Epimedium brevicornum; inflammation; macrophage; mouse; nonhuman; prostaglandin synthesis

MeSH: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Epimedium; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Plant Extracts
Medline is the source for the MeSH terms of this document.

Species Index: Berberidaceae; Epimedium brevicornum


Chemicals and CAS Registry Numbers: gamma interferon inducible protein 10, 97741-20-3; nitric oxide, 10102-43-9; prostaglandin E2, 363-24-6; vasculotropin, 127464-60-2;Anti-Inflammatory Agents; Cytokines; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Nitric Oxide, 10102-43-9; Plant Extracts


ISSN: 0951418X CODEN: PHYRESource Type: Journal Original language: English
DOI: 10.1002/ptr.3161 PubMed ID: 20564498 Document Type: Article
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