Date: January 2011

Journal: Phytotherapy Research Volume 25, Issue 1, January 2011, Pages 1-10 , Doi: 10.1002/ptr.3224

2011 | Antiangiogenic phytochemicals and medicinal herbs…

Jeong, S.-J.a, Koh, W.a, Lee, E.-O.a, Lee, H.-J.a, Lee, H.-J.a, Bae, H.a, Lü, J.b, Kim, S.-H.a


Medicinal herbs and their phytochemicals are potential novel leads for developing antiangiogenic drugs. This review aims to assess the current status of research with medicinal herbs and their phytochemicals for the development of antiangiogenic agents for cancer and other angiogenesis-related diseases including inflammation, diabetic retinopathy, endometriosis and obesity. Most studies reviewed have focused on vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor 2 (VEGFR-2) signaling for endothelial response processes and have led to the identification of many potential antiangiogenic agents. Since human clinical trials with antiangiogenic modalities targeting VEGF/VEGFR-2 signaling have shown limited efficacy and occasional toxic side effects, screening strategies for herbal phytochemicals based on other signaling pathways important for cancer-endothelial and stromal crosstalks should be emphasized in the future. © 2010 John Wiley & Sons, Ltd.

Author keywords

angiogenic diseases; antiangiogenesis; medical herbs; phytochemicals; VEGF/VEGFR

Indexed keywords

EMTREE drug terms: angiostatin; antirheumatic agent; apigenin; bevacizumab; caffeic acid; campesterol; celastrol; coumarin derivative; curcumin; delphinidin; ellagic acid; endostatin; epigallocatechin gallate; farnesiferol c; fisetin; flavone; gallic acid; genistein; guggulsterone; hypericin; paeoniflorin; plant medicinal product; quercetin; resveratrol; scopolin; solimastat; sulforaphane; tannin; thymoquinone; unclassified drug; unindexed drug

EMTREE medical terms: antiangiogenic activity; clinical trial; diabetic retinopathy; drug mechanism; drug screening; endometriosis; herb; human; inflammation; metastasis; neoplasm; nonhuman; obesity; review; rheumatoid arthritis

MeSH: Angiogenesis Inhibitors; Animals; Diabetic Retinopathy; Endometriosis; Female; Humans; Mice; Neoplasms; Neovascularization, Pathologic; Obesity; Phytotherapy; Plants, Medicinal; Signal Transduction; Vascular Endothelial Growth Factor A
Medline is the source for the MeSH terms of this document.

Chemicals and CAS Registry Numbers: angiostatin, 172642-30-7, 86090-08-6; apigenin, 520-36-5; bevacizumab, 216974-75-3; caffeic acid, 27323-69-9, 331-39-5; campesterol, 474-62-4; celastrol, 34157-83-0; curcumin, 458-37-7; delphinidin, 528-53-0; ellagic acid, 476-66-4; endostatin, 187888-07-9; epigallocatechin gallate, 989-51-5; fisetin, 528-48-3; flavone, 525-82-6; gallic acid, 149-91-7; genistein, 446-72-0; guggulsterone, 39025-23-5, 39025-24-6, 95975-55-6; hypericin, 548-04-9; paeoniflorin, 23180-57-6; quercetin, 117-39-5; resveratrol, 501-36-0; scopolin, 531-44-2; sulforaphane, 142925-33-5, 4478-93-7; tannin, 1401-55-4; thymoquinone, 490-91-5;Angiogenesis Inhibitors; Vascular Endothelial Growth Factor A

ISSN: 0951418X CODEN: PHYRESource Type: Journal Original language: English
DOI: 10.1002/ptr.3224 PubMed ID: 20564543 Document Type: Review
  • 페이스북으로 보내기
  • 트위터로 보내기
  • 미투데이로 보내기
  • 구글플러스로 보내기