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Antiangiogenic phytochemicals and medicinal herbs

  • AD 최고관리자
  • 조회 1560
  • 2014.12.16

Abstract

Medicinal herbs and their phytochemicals are potential novel leads for developing antiangiogenic drugs. This review aims to assess the current status of research with medicinal herbs and their phytochemicals for the development of antiangiogenic agents for cancer and other angiogenesis-related diseases including inflammation, diabetic retinopathy, endometriosis and obesity. Most studies reviewed have focused on vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor 2 (VEGFR-2) signaling for endothelial response processes and have led to the identification of many potential antiangiogenic agents. Since human clinical trials with antiangiogenic modalities targeting VEGF/VEGFR-2 signaling have shown limited efficacy and occasional toxic side effects, screening strategies for herbal phytochemicals based on other signaling pathways important for cancer-endothelial and stromal crosstalks should be emphasized in the future. © 2010 John Wiley & Sons, Ltd.


Author keywords

angiogenic diseases; antiangiogenesis; medical herbs; phytochemicals; VEGF/VEGFR


Indexed keywords

EMTREE drug terms: angiostatin; antirheumatic agent; apigenin; bevacizumab; caffeic acid; campesterol; celastrol; coumarin derivative; curcumin; delphinidin; ellagic acid; endostatin; epigallocatechin gallate; farnesiferol c; fisetin; flavone; gallic acid; genistein; guggulsterone; hypericin; paeoniflorin; plant medicinal product; quercetin; resveratrol; scopolin; solimastat; sulforaphane; tannin; thymoquinone; unclassified drug; unindexed drug

EMTREE medical terms: antiangiogenic activity; clinical trial; diabetic retinopathy; drug mechanism; drug screening; endometriosis; herb; human; inflammation; metastasis; neoplasm; nonhuman; obesity; review; rheumatoid arthritis

MeSH: Angiogenesis Inhibitors; Animals; Diabetic Retinopathy; Endometriosis; Female; Humans; Mice; Neoplasms; Neovascularization, Pathologic; Obesity; Phytotherapy; Plants, Medicinal; Signal Transduction; Vascular Endothelial Growth Factor A
Medline is the source for the MeSH terms of this document.


Chemicals and CAS Registry Numbers: angiostatin, 172642-30-7, 86090-08-6; apigenin, 520-36-5; bevacizumab, 216974-75-3; caffeic acid, 27323-69-9, 331-39-5; campesterol, 474-62-4; celastrol, 34157-83-0; curcumin, 458-37-7; delphinidin, 528-53-0; ellagic acid, 476-66-4; endostatin, 187888-07-9; epigallocatechin gallate, 989-51-5; fisetin, 528-48-3; flavone, 525-82-6; gallic acid, 149-91-7; genistein, 446-72-0; guggulsterone, 39025-23-5, 39025-24-6, 95975-55-6; hypericin, 548-04-9; paeoniflorin, 23180-57-6; quercetin, 117-39-5; resveratrol, 501-36-0; scopolin, 531-44-2; sulforaphane, 142925-33-5, 4478-93-7; tannin, 1401-55-4; thymoquinone, 490-91-5;Angiogenesis Inhibitors; Vascular Endothelial Growth Factor A


ISSN: 0951418X CODEN: PHYRESource Type: Journal Original language: English
DOI: 10.1002/ptr.3224 PubMed ID: 20564543 Document Type: Review
트위터 페이스북 미투데이 다음요즘 싸이공감 카카오톡 카카오스토리 네이트온 쪽지 구글 북마크 네이버 북마크

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