PM021, which consists of two herbal components, Mori Folium and Aurantii Fructus, is routinely used to treat diabetes in Korea. In this study, the anti-diabetic effect of PM021 on an animal model of developing type 2 diabetes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats was investigated. Eight weeks of age male OLETF rats were treated daily with PM021 or vehicle for five months. Specifically, changes in body weight, blood glucose, urine volume, food intake and oral glucose tolerance were measured in rats for five months. The rats in this study were divided into four groups: a Long-Evans Tokushima Otsuka (LETO) rat group, which is a genetic control group for OLETF, that received no treatment; a PM021 treatment group of LETO rats; OLETF rats that received no treatment; and OLETF rats that received PM021 treatment. The results showed that PM021 significantly prevented increases in body weight, blood glucose, and urine and food intake that resulted from the induction of obesity and diabetes. PM021 also improved glucose tolerance in OLETO rats. However, PM021 had no effect on LETO rats, a control group of OLETF rats. Taken together, these findings indicate that PM021 has distinct anti-diabetic effects without any adverse effects or toxicities. © 2011 Elsevier Ireland Ltd.
Diabetes; LETO; OLETF
EMTREE drug terms: glucose; herbaceous agent
EMTREE medical terms: animal experiment; animal model; antidiabetic activity; article; Aurantii fructus; blood glucose monitoring; controlled study; diabetic obesity; drug effect; drug mechanism; female; food intake; genetic regulation; glucose blood level; herb; herbal medicine; male; Mori Folium; non insulin dependent diabetes mellitus; nonhuman; oral glucose tolerance test; Otsuka Long Evans Tokushima fatty rat; rat; toxicity testing; treatment duration; urine volume; weight change
MeSH: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drug Toxicity; Eating; Hypoglycemic Agents; Male; Plant Preparations; Rats; Rats, Inbred OLETF; Urine
Medline is the source for the MeSH terms of this document.
Chemicals and CAS Registry Numbers: glucose, 50-99-7, 84778-64-3;Blood Glucose; Hypoglycemic Agents; Plant Preparations
Manufacturers:Drug manufacturer: Sun Ten, Taiwan.