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Anti-diabetic effect of standardized herbal formula PM021 consisting of Mori Folium and Aurantii Fructus on type II diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats

  • AD 최고관리자
  • 조회 2629
  • 2014.12.16

Abstract

PM021, which consists of two herbal components, Mori Folium and Aurantii Fructus, is routinely used to treat diabetes in Korea. In this study, the anti-diabetic effect of PM021 on an animal model of developing type 2 diabetes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats was investigated. Eight weeks of age male OLETF rats were treated daily with PM021 or vehicle for five months. Specifically, changes in body weight, blood glucose, urine volume, food intake and oral glucose tolerance were measured in rats for five months. The rats in this study were divided into four groups: a Long-Evans Tokushima Otsuka (LETO) rat group, which is a genetic control group for OLETF, that received no treatment; a PM021 treatment group of LETO rats; OLETF rats that received no treatment; and OLETF rats that received PM021 treatment. The results showed that PM021 significantly prevented increases in body weight, blood glucose, and urine and food intake that resulted from the induction of obesity and diabetes. PM021 also improved glucose tolerance in OLETO rats. However, PM021 had no effect on LETO rats, a control group of OLETF rats. Taken together, these findings indicate that PM021 has distinct anti-diabetic effects without any adverse effects or toxicities. © 2011 Elsevier Ireland Ltd.


Author keywords

Diabetes; LETO; OLETF


Indexed keywords

EMTREE drug terms: glucose; herbaceous agent

EMTREE medical terms: animal experiment; animal model; antidiabetic activity; article; Aurantii fructus; blood glucose monitoring; controlled study; diabetic obesity; drug effect; drug mechanism; female; food intake; genetic regulation; glucose blood level; herb; herbal medicine; male; Mori Folium; non insulin dependent diabetes mellitus; nonhuman; oral glucose tolerance test; Otsuka Long Evans Tokushima fatty rat; rat; toxicity testing; treatment duration; urine volume; weight change

MeSH: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drug Toxicity; Eating; Hypoglycemic Agents; Male; Plant Preparations; Rats; Rats, Inbred OLETF; Urine
Medline is the source for the MeSH terms of this document.


Chemicals and CAS Registry Numbers: glucose, 50-99-7, 84778-64-3;Blood Glucose; Hypoglycemic Agents; Plant Preparations

Manufacturers:Drug manufacturer: Sun Ten, Taiwan.


ISSN: 01688227 CODEN: DRCPESource Type: Journal Original language: English
DOI: 10.1016/j.diabres.2011.03.037 PubMed ID: 21524812 Document Type: Article
트위터 페이스북 미투데이 다음요즘 싸이공감 카카오톡 카카오스토리 네이트온 쪽지 구글 북마크 네이버 북마크

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