Abstract

Cisplatin is an effective chemotherapeutic agent that is used for the treatment of a variety of cancers; however, its nephrotoxicity limits the use of this drug. In the present study, we examined whether paeonol, a major compound of Moutan Cortex, has protective effects on cisplatin-induced acute renal failure in mice. To accomplish this, Balb/c mice (6 to 8 wk of age, weighing 20 to 25 g) were administered, Moutan Cortex (300 mg/kg) or paeonol (20 mg/kg) once a day. At day 4, mice received cisplatin (30, 20, or 10 mg/kg) intraperitoneally. The paeonol-treated group showed marked attenuation of serum creatine and blood urea nitrogen levels as well as reduced levels of proinflammatory cytokines and nitric oxide when compared to the control group. In addition, the paeonol-treated group showed prolonged survival and marked attenuation of renal tissue injury. Taken together, these results demonstrated that paeonol can prevent the renal toxic effects of cisplatin. © 2013 Hyojung Lee et al.

Indexed keywords

EMTREE drug terms: cisplatin; creatine; interleukin 1beta; nitric oxide; peonol; protective agent; tumor necrosis factor alpha; urea

EMTREE medical terms: acute kidney failure; animal experiment; animal model; animal tissue; article; attenuation; comparative study; controlled study; creatine kinase blood level; drug effect; drug induced disease; male; mouse; nonhuman; Paeonia suffruticosa; priority journal; renal protection; survival; urea nitrogen blood level

Chemicals and CAS Registry Numbers: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; creatine, 57-00-1; nitric oxide, 10102-43-9; peonol, 552-41-0; urea, 57-13-6