Abstract

Cisplatin is an effective chemotherapy used to treat tumors. However, the use of cisplatin is limited due to side effects, mainly nephrotoxicity. Pulsatillae Radix is known to possess anti-inflammatory activities. The aim of this study was to test the protective effect of Pulsatilla Radix on cisplatin-induced renal failure in mice. Pulsatillae Radix was administered (300 mg/kg p.o.) once a day for 3 days. At day 3, all groups of mice received a single injection of cisplatin (25 mg/kg i.p.). Pulsatillae Radix treatment ameliorated renal dysfunction 72 h after cisplatin administration. Mice treated with Pulsatillae Radix showed significantly reduced levels of pro-inflammatory cytokines compared to the control group. Moreover, Pulsatillae Radix did not disturb the anti-tumor effect of cisplatin in tumor-bearing mice. These results showed that Pulsatillae Radix has renoprotective effects and may represent a new treatment strategy in cisplatin-induced nephrotoxicity. © 2013 The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media Dordrecht.

Author keywords

Cisplatin; Nephrotoxicity; Pulsatilla; Pulsatillae Radix; Tumor-bearing mice

Indexed keywords

EMTREE drug terms: cisplatin; creatinine; interleukin 1beta; interleukin 6; plant extract; protective agent; Pulsatillae extract; tumor necrosis factor alpha; unclassified drug

EMTREE medical terms: animal experiment; animal model; antineoplastic activity; article; comparative study; controlled study; creatinine blood level; drug effect; glomerulus; kidney failure; kidney parenchyma; kidney tubule necrosis; mouse; nephrotoxicity; nonhuman; protein blood level; Pulsatilla; renal protection; single drug dose; tumor volume; tumor xenograft; urea nitrogen blood level

Chemicals and CAS Registry Numbers: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; creatinine, 19230-81-0, 60-27-5