Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to airway remodeling and the deterioration of lung function. Viticis Fructus (VF) has long been used in China and Korea as a traditional herbal remedy for treating various inflammatory diseases. Previously, we have isolated a novel phytochemical, pyranopyran-1, 8-dione (PPY), from VF. This study was conducted to evaluate the ability of PPY to prevent airway inflammation and to attenuate airway responses in a cockroach allergen-induced asthma model in mice. The mice sensitized to and challenged with cockroach allergen were treated with oral administration of PPY. The infiltration of total cells, eosinophils and lymphocytes into the BAL fluid was significantly inhibited in cockroach allergen-induced asthma mice treated with PPY (1, 2, or 10 mg/kg). Th2 cytokines and chemokine, such as IL-4, IL-5, IL-13 and eotaxin in BAL fluid were also reduced to normal levels following treatment with PPY. In addition, the levels of IgE were also markedly suppressed after PPY treatment. Histopathological examination demonstrated that PPY substantially inhibited eosinophil infiltration into the airway, goblet cell hyperplasia and smooth muscle hypertrophy. Taken together, these results demonstrate that PPY possesses a potent efficacy on controlling allergic asthma response such as airway inflammation and remodeling. © 2014 Park et al.
EMTREE drug terms: allergen; antiasthmatic agent; eotaxin; interleukin 13; interleukin 4; interleukin 5; montelukast; pyranopyran 1, 8 dione; unclassified drug
EMTREE medical terms: airway; allergic asthma; animal experiment; animal model; animal tissue; antibody titer; antiinflammatory activity; article; cell proliferation; cockroach; controlled study; cytokine production; disease severity; drug efficacy; drug safety; enzyme linked immunosorbent assay; immunohistochemistry; lung function; lung lavage; male; mouse; nonhuman; Th2 cell; Vitex rotundifolia
MeSH: Administration, Oral; Airway Remodeling; Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Cockroaches; Cytokines; Drug Evaluation, Preclinical; Lung; Male; Mice; Mice, Inbred BALB C; Pyrones; Th2 Cells
Medline is the source for the MeSH terms of this document.
Chemicals and CAS Registry Numbers: interleukin 13, 148157-34-0; montelukast, 151767-02-1, 158966-92-8