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기타논문
Date: 27 November 2012

Journal: British Journal of Nutrition Volume 110, Issue 1, 14 July 2013, Pages 69-76 , Doi: 10.1017/S0007114512004734

2012 | Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice…

Hyojung Leea1, Hyunseong Kima1, Gihyun Leea1, Hwan-Suck Chunga1 and Hyunsu Baea1 c1

Abstract

Curcumin has been used in Asian traditional medicine for its medicinal properties. Recent studies have demonstrated that curcumin has antioxidant, anti-tumour and anti-inflammatory activities. The aim of the present study is to investigate the effects of curcumin on established lupus nephritis (LN) in New Zealand Black/White (NZB/W) F1 female mice, in particular, its interaction with regulatory T (Treg) cells. Starting at 18 weeks of age, mice were fed a standard diet or a diet containing 1 % curcumin until the end of the study. The proteinuria level and the serum levels of IgG1, IgG2a and anti-double-stranded DNA (dsDNA) IgG antibodies were measured. Additionally, IgG immune complex deposition in the glomeruli and renal inflammation were compared between curcumin-treated mice and control mice. Curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a and anti-dsDNA IgG antibodies in NZB/W F1 female mice. IgG immune complex deposition in the glomeruli was reduced in curcumin-treated mice. Furthermore, renal inflammation was also decreased after curcumin treatment. Interestingly, these therapeutic effects of curcumin disappeared after Treg depletion by anti-CD25 antibody injection. Curcumin exerted a protective effect against LN in NZB/W F1 mice. We speculate that the protective effects of curcumin in LN may involve, at least in part, its interaction with Treg cells.


 TITLE
 Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice
 JOURNAL
 British Journal of Nutrition
 Volume 110, Issue 1, 14 July 2013, Pages 69-76
 DOI
 10.1017/S0007114512004734 (click 하시면 DOI 검색 결과가 새창으로 나타납니다.)
 
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