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Molecular determinants of selectivity in 5-hydroxytryptamine(1B) receptor-G protein interactions
새창
Abstract The recognition between G protein and cognate receptor plays a key role in specific cellular responses to environmental stimuli. Here we explore specificity in receptor-G protein coupling by taking advantage of the ability of the 5-hydroxytryptamine(1B) (5-HT(1B)) receptor to discriminate …
최고관리자 2014-12-16 12:49:35 -
Mapping of effector binding sites of transducin α-subunit using Gαt/Gαi1 chimeras
새창
Abstract The G protein transducin has been an often-used model for biochemical, structural, and mechanistic studies of G protein function. Experimental studies have been limited, however, by the inability to express quantities of mutants in heterologous systems with ease. In this study we have made…
최고관리자 2014-12-16 12:46:44