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Evaluation of the Efficacy and Safety of the Herbal Formula PM014 in a Cisplatin- and Paclitaxel-Treated Tumor-Bearing Mouse Model
새창
AbstractPM014 (HL301) is a standardized herbal mixture derived from a traditional Korean medicine, Chung-Sang-Bo-Ha-Tang. Previously, we reported that PM014 treatment significantly suppressed pulmonary fibrosis, one of the frequent adverse effects of anticancer therapy in lung cancer. Before the cli…
최고관리자 2020-10-29 15:19:57 -
Standardized herbal extract PM014 alleviates fine dust-induced lung inflammation in mice
새창
Background: Fine dust penetrates deep into the human alveoli, and the fine dust accumulated in the bronchus and lungs can directly trigger various respiratory diseases. PM014 (HL301) is the herbal extract derived from the herbal medicine Chung-Sang-Bo-Ha-Tang which is used for the treatment of lun…
최고관리자 2020-10-29 15:05:57 -
Prophylactic Effects of Bee Venom Phospholipase A2 in Lipopolysaccharide-Induced Pregnancy Loss
새창
AbstractSpontaneous abortion represents a common form of embryonic loss caused by early pregnancy failure. In the present study, we investigated the prophylactic effects of bee venom phospholipase A2 (bvPLA2), a regulatory T cell (Treg) inducer, on a lipopolysaccharide (LPS)-induced abortion mouse…
최고관리자 2019-07-26 15:00:28 -
Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung
새창
Cigarette smoke (CS) is considered as a major risk factor for pulmonary and intestinal inflammation. CS leads to macrophage infiltration in the mucosae of the lung and colon, inducing the uncontrolled secretion of inflammatory mediators, and thus promoting inflammatory response. In this study, we in…
최고관리자 2018-11-16 15:15:04 -
Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor
새창
Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitroch…
최고관리자 2018-11-16 15:10:46 -
Pyranopyran-1,8-dione, an Active Compound from Vitices Fructus, Attenuates Cigarette-Smoke Induced Lung Inflammation in Mice
새창
1. Introduction During the last twenty years, new anti-inflammatory drugs are being discovered and developed as anti-cytokine agents with the massive expansion of the study on inflammatory response [1,2]. People, however, still long for cheaper and more effective alternative approaches to treat …
최고관리자 2017-07-26 08:49:25 -
Immunotherapy with methyl gallate, an inhibitor of Treg cell migration, enhances the anti-cancer effect of cisplatin therapy
새창
Abstract Foxp3+ CD25+CD4+ regulatory T (Treg) cells are crucial for the maintenance of immunological self-tolerance and are abundant in tumors. Most of these cells are chemo-attracted to tumor tissues and suppress anti-tumor responses inside the tumor. Currently, several cancer immunoth…
최고관리자 2016-07-12 14:43:11 -
Anti-Inflammatory Applications of Melittin, a Major Component of Bee Venom: Detailed Mechanism of Action and Adverse Effects
새창
Abstract: Inflammation is a pervasive phenomenon triggered by the innate and adaptive immune systems to maintain homeostasis. The phenomenon normally leads to recovery from infection and healing, but when not properly phased, inflammation may cause immune disorders. Bee venom is a toxin that bees us…
최고관리자 2016-05-12 15:52:24 -
Tuberostemonine N, an active compound isolated from Stemona tuberosa, suppresses cigarette smoke-induced sub-acute lung inflammation in mice
새창
http://dx.doi.org/10.1016/j.phymed.2015.11.015
최고관리자 2016-01-18 09:41:49 -
Adenoviral gene transfer of acetylcholinesterase T subunit in the hypothalamus potentiates electroacupuncture analgesia in rats
새창
Keywords: Acetylcholinesterase; adenovirus; electroacupuncture analgesia; hypothalamus; microarray; non-responder; rats; real-time RT-PCR; responder Our previous studies, using cDNA microarray and real-time reverse transcription-polymerase chain reaction, showed that acetylcholin…
최고관리자 2013-08-19 22:21:22