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대표논문 게시판 내 결과
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The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis
새창
Abstract Nuclear factor of activated T cells (NFAT) transcription factors regulate gene expression in lymphocytes and control cardiac valve formation. Here, we report that NFATp regulates chondrogenesis in the adult animal. In mice lacking NFATp, resident cel…
최고관리자 2013-08-19 22:26:08 -
Two amino acids within the helix of Gα(i1) mediate coupling with 5- hydroxytryptamine(1B) receptors
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Abstract We previously reported that residues 299–318 in Gαi1 participate in the selective interaction between Gαi1 and the 5-hydroxytryptamine1B(5-HT1B) receptor (Bae, H., Anderson, K., Flood, L. A., Skiba, N. P., Hamm, H. E., and Graber, S. G. (1997)J. Biol. Chem. 272, 32071–32077). The present…
최고관리자 2013-08-20 00:35:27 -
The α-helical domain of Gα(t) determines specific interaction with regulator of G protein signaling 9
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Abstract RGS proteins (regulators of G protein signaling) are potent accelerators of the intrinsic GTPase activity of G protein α subunits (GAPs), thus controlling the response kinetics of a variety of cell signaling processes. Most RGS domains that have been studied …
최고관리자 2013-08-20 00:37:16 -
Molecular basis for interactions of G protein βΓ subunits with effectors
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ABSTRACT Both the α and βγ subunits of heterotrimeric guanine nucleotide–binding proteins (G proteins) communicate signals from receptors to effectors. Gβγ subunits can regulate a diverse array of effectors, including ion channels and enzymes. Gα subunits bound …
최고관리자 2013-08-20 00:48:00 -
Molecular determinants of selectivity in 5-hydroxytryptamine(1B) receptor-G protein interactions
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Abstract The recognition between G protein and cognate receptor plays a key role in specific cellular responses to environmental stimuli. Here we explore specificity in receptor-G protein coupling by taking advantage of the ability of the 5-hydroxytryptamine1B (5-HT1B) recepto…
최고관리자 2013-08-20 00:56:00 -
Mapping of effector binding sites of transducin α-subunit using Gαt/Gαi1 chimeras
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TITLE Mapping of effector binding sites of transducin α-subunit using Gαt/Gαi1 chimeras JOURNAL Journal of Biological Chemistry Volume 271, Issue 1, 5 January 1996, Pages 413-424 PUBMED ID 10.1074/jbc.271.…
최고관리자 2013-08-20 00:58:15
기타논문 게시판 내 결과
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Enhanced Therapeutic Effect of Optimized Melittin-dKLA, a Peptide Agent Targeting M2-like Tumor-Associated Macrophages in Triple-Negative Breast Cancer
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DOI https://doi.org/10.3390/ijms232415751 JOURNAL International Journal of Molecular Sciences TITLE Enhanced Therapeutic Effect of Optimized Melittin-dKLA, a Peptide Agent Targeting M2-like Tumor-As…
최고관리자 2022-12-16 14:32:59 -
Particulate Matter Exacerbates the Death of Dopaminergic Neurons in Parkinson’s Disease through an Inflammatory Response
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Abstract: Particulate matter (PM), a component of air pollution, has been epidemiologically associated with a variety of diseases. Recent reports reveal that PM has detrimental effects on the brain. In this study, we aimed to investigate the biological effects of ambient particles on the neurodege…
최고관리자 2022-06-16 08:38:17 -
Loss of SP-A in the Lung Exacerbates Pulmonary Fibrosis
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Abstract: Idiopathic pulmonary fibrosis (IPF) is a devastating and common chronic lung disease that is pathologically characterized by the destruction of lung architecture and the accumulation of extracellular matrix in the lung. Previous studies have shown an association between lung surfactant …
최고관리자 2022-06-16 08:31:14 -
Therapeutic Effect of Melittin–dKLA Targeting Tumor-Associated Macrophages in Melanoma
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Abstract: Melanoma is an immunogenic tumor and a serious type of skin cancer. Tumor-associated macrophages (TAMs) express an M2-like phenotype and are involved in all stages of melanomagenesis; it is hence a promising target for cancer immunotherapy. We herein investigated whethe…
최고관리자 2022-03-15 10:14:59