경희대학교 한의과대학 배현수 교수 연구실
Prof. Hyunsu Bae / College of Korean Medicine, Kyung Hee Univeristy, Seoul, Korea
on 전체검색 결과
- 게시판
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- 게시물
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Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson’s disease alpha-synuclein transgenic mice
새창
DOI 10.1038/emm.2016.49 JOURNAL Experimental & Molecular Medicine TITLE Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson’s disease al…
최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 2016-07-12 14:38:37 -
Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson’s Disease
새창
Foxp3-expressing CD4+ regulatory T cells (Tregs) are vital for maintaining immune tolerance in animal models of various immune diseases. In the present study, we demonstrated that bee venom phospholipase A2 (bvPLA2) is the major BV compound capable of inducing Treg expansion and promotes the surviva…
최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 2015-11-16 09:04:30 -
Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson's disease: Role of regulatory T cells
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Abstract In the present study, we sought to determine whether bee venom (BV) promotes the survival of dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD). Treatment with BV prevented degeneration of DA neurons in the substanti…
최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 2013-08-19 22:02:14 -
Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells
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Abstract CD4+CD25+ regulatory T (Treg) cells play crucial roles in the host response to tumors. Increasing evidence supports the existence of elevated numbers of Treg cells in solid tumors and hematologic malignancies. In this study, the effects of methyl gallate …
최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 2013-08-19 22:14:24 -
Foxp3 is a novel repressor of microglia activation
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Abstract Forkhead transcription factor3 (Foxp3) is critical for generating CD4+CD25+ regulatory T cells. However, its role in microglia has not been identified. Here, we show that Foxp3 is expressed in microglia and is upregulated upon activation. In Foxp3 mutant mice (Foxp3sf), microglia relea…
최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 2013-08-19 22:16:06 -
The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis
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Abstract Nuclear factor of activated T cells (NFAT) transcription factors regulate gene expression in lymphocytes and control cardiac valve formation. Here, we report that NFATp regulates chondrogenesis in the adult animal. In mice lacking NFATp, resident cel…
최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 2013-08-19 22:26:08 -
The α-helical domain of Gα(t) determines specific interaction with regulator of G protein signaling 9
새창
Abstract RGS proteins (regulators of G protein signaling) are potent accelerators of the intrinsic GTPase activity of G protein α subunits (GAPs), thus controlling the response kinetics of a variety of cell signaling processes. Most RGS domains that have been studied …
최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 2013-08-20 00:37:16 -
Molecular basis for interactions of G protein βΓ subunits with effectors
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ABSTRACT Both the α and βγ subunits of heterotrimeric guanine nucleotide–binding proteins (G proteins) communicate signals from receptors to effectors. Gβγ subunits can regulate a diverse array of effectors, including ion channels and enzymes. Gα subunits bound …
최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 2013-08-20 00:48:00 -
Molecular determinants of selectivity in 5-hydroxytryptamine(1B) receptor-G protein interactions
새창
Abstract The recognition between G protein and cognate receptor plays a key role in specific cellular responses to environmental stimuli. Here we explore specificity in receptor-G protein coupling by taking advantage of the ability of the 5-hydroxytryptamine1B (5-HT1B) recepto…
최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 2013-08-20 00:56:00